Adjuvants & Safety
The first adjuvants were developed with the aim of increasing the antibody response, and this single requirement was
sufficient. However, the issue of post-vaccination reactions has always been of concern to patients and health
professionals. Some types of adjuvants may cause local reactions to the vaccine (redness, pain, local increase in
temperature, indurations) or general reactions (increase in temperature, hypersensitivity reactions). Generally,
they do not worsen the benefit/risk ratio of vaccination, and many vaccines simply would not work without the
addition of such components.